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North Greenwich station, served by the Jubilee Line, is the primary Tube station for The O2. It is located directly adjacent to the venue, meaning there's no significant walk, making it incredibly convenient for attendees. The Jubilee Line connects directly to major hubs like London Bridge, Waterloo, Westminster, and Bond Street, offering easy access from across London. Frequent services run throughout the day, typically every 2-3 minutes during peak times and every 5-10 minutes off-peak. From London's major train termini, you can connect to the Jubilee Line: for example, from King's Cross St. Pancras (direct access to Jubilee Line), journey time is approximately 20 minutes. From Euston, you would take the Victoria Line to Green Park and change for the Jubilee Line, taking around 25-30 minutes. The station itself offers ticket machines, accessibility features, and staff assistance.

Several bus routes serve The O2, with the main stop located right outside the venue at North Greenwich. Key routes include the 108, which runs 24/7 between Lewisham and Stratford, passing through key areas of East London. The 486 route connects to Greenwich and Bexleyheath, while the 472 travels between Camberwell and North Greenwich. For those coming from further afield, routes like the 132 connect to Greenwich, and the 161 links to Upminster. Night bus services, particularly the 108, ensure accessibility throughout the night, providing a reliable option for late-finish events. Journey times from central London destinations like London Bridge or the City can vary significantly depending on traffic, but typically range from 30 to 60 minutes. Major operators include TfL Buses.

For drivers heading to The O2, the venue is conveniently located just off the A102, which connects to the Blackwall Tunnel. If approaching from the M25, exit at Junction 2 to take the A2 towards London, then follow signs for the Blackwall Tunnel (A102 Southbound). The A102 exit for The O2 is clearly signposted. The postcode for sat-nav is SE10 0DX. Parking is available on-site at The O2 in the Indigo car park, which is a multi-storey facility. Rates typically range from around £7-£10 for up to 2 hours, with daily maximums often around £25-£30, though prices can vary for major events. There are no dedicated park and ride facilities for The O2; however, the North Greenwich Underground station is served by TfL’s Bus Rapid Transit (BRT) network from Thamesmead, which could be considered a form of park and ride. The Indigo car park offers disabled parking bays, and lifts are available for access to the arena.

The O2 Arena is committed to providing excellent accessibility for all visitors. Wheelchair access is available throughout the venue, with dedicated entrances, lifts providing access to all levels, and a range of accessible seating locations offering clear views of the stage. Accessible toilets are situated on all levels and are clearly signposted. Induction loop systems are available for those with hearing impairments; please enquire at the venue's customer service desk for assistance. Assistance dogs are welcome in the venue, and staff are trained to provide support to visitors with disabilities. Accessible parking bays are available in the Indigo car park, close to the arena entrances. The O2's dedicated accessibility team is available to assist guests, and visitors are encouraged to contact the venue in advance to discuss specific needs and ensure a comfortable experience.